1. Overview of 2,4-Dichlorobenzyl Chloride
2,4-Dichlorobenzyl Chloride (CAS 94-99-5) is an important halogenated aromatic benzyl chloride compound, widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals and dyes.
SNOWHITE CHEMICAL CO., LTD supplies bulk industrial grade and pharmaceutical intermediate products, with mature side-chain chlorination technology, strict isomer separation and impurity control, compliant with industrial production and pharmaceutical R&D standards.
Our products are widely used in large-scale API synthesis, fungicide manufacturing, dye production and specialty chemical processing worldwide, with stable batch consistency and reliable quality.
Basic Chemical Information：
Chemical Name: 2,4-Dichlorobenzyl Chloride
Molecular Formula: C₇H₅Cl₃
Molecular Weight: 195.47g/mol
CAS No.: 94-99-5
EINECS No.: 202-381-0
HS Code: 29036990
Appearance: Colorless to pale yellow transparent oily liquid
1.1 Physicochemical Properties
Melting Point: -2.6℃ (lit.)
Boiling Point: 248℃ (atmospheric pressure, lit.)
Solubility: Slightly soluble in water, toluene, chloroform, dichloromethane, ethanol and other common organic solvents
Stability: Stable under normal sealed conditions, avoid strong oxidizing agents and strong alkalis to prevent hydrolysis and decomposition; keep away from open flames and high temperatures
1.2 Functional Performance and Mechanism
The industrial application value of 2,4-Dichlorobenzyl Chloride comes from the synergistic effect of the benzyl chloride group (-CH₂Cl) and the 2,4-dichloro substituents on the benzene ring, which is the core difference from other isomers:
The benzyl chloride group has high nucleophilic substitution reactivity, which can efficiently participate in condensation, substitution and other reactions, and is easy to introduce benzyl groups into downstream products, with high reaction conversion rate and few by-products.
The 2,4-dichloro substituents on the benzene ring have obvious electron-withdrawing effect and appropriate steric hindrance, which can regulate the reaction regioselectivity of downstream synthesis, and is the key structural basis for ensuring the biological activity of pharmaceutical and agrochemical products.
1.2.1 Practical Application Significance
The unique disubstituted benzyl chloride structure of this product brings exclusive application advantages in industrial production:
Pharmaceutical field: It is the core intermediate for the synthesis of antifungal drugs such as miconazole and fungicides such as diclobutrazol, and the 2,4-dichlorophenyl structure can enhance the bactericidal activity and bioavailability of drugs.
Agrochemical field: It is an important intermediate for the synthesis of high-efficiency and broad-spectrum fungicides such as diclobutrazol, which can improve the selective bactericidal effect of pesticides and ensure crop safety.
Dye field: It is used as a building block for the synthesis of high-performance azo dyes, which can enhance the light fastness and wash fastness of dyes, and is compatible with existing large-scale dye production lines.
2. Pharmaceutical Grade
2.1 Product Overview
With strict control of isomers, residual solvents and harmful impurities, compliant with ICH Q7 and pharmaceutical intermediate quality requirements, exclusively used as a key intermediate for large-scale API synthesis. SNOWHITE CHEMICAL CO., LTD can provide customized quality standards and complete quality research documents according to your synthetic route.
2.2 Typical Applications
Mainly used in the synthesis of core intermediates for antifungal drugs (such as miconazole) and fungicides (such as diclobutrazol), directly participating in the construction of drug pharmacophores, with strict batch-to-batch consistency to ensure the safety and stability of final APIs; also used in medicinal chemistry research to optimize drug molecular structures.
3. Industrial Grade
3.1 Product Overview
Used for large-scale synthesis of agrochemicals, dyes and specialty chemicals, focusing on production yield, cost control and stable bulk supply capacity, with mature production technology to meet the needs of conventional industrial production.
3.2 Typical Applications
Widely used as a core building block for the industrial production of fungicides and herbicides, ensuring high bactericidal and herbicidal activity and production yield; also used in the synthesis of 2,4-dichlorobenzyl alcohol, 2,4-dichlorobenzaldehyde, 2,4-dichlorobenzonitrile and other fine chemical intermediates, and in the production of high-performance dyes to improve product performance.
4. Industrial Synthesis Processes
Industrial production of 2,4-Dichlorobenzyl Chloride by SNOWHITE CHEMICAL CO., LTD mainly adopts 2,4-dichlorotoluene side-chain chlorination process, with azobisisobutyronitrile or using radical initiators such as AIBN under controlled conditions, chlorination reaction under light conditions, and the reaction process is tracked by GC to control the chlorination degree. The technology is mature, with stable isomer control, high conversion rate and good batch consistency.
5. Quality Control and Testing
SNOWHITE CHEMICAL CO., LTD has established a strict graded quality control system, with isomer separation and detection as the core control procedure for Pharmaceutical Grade, to ensure that the product quality meets the requirements of different application scenarios.
Main Testing Items & Standards:
Assay: Industrial Grade ≥98.5%, Pharmaceutical Grade ≥99.0% (determined by GC)
Melting Point: -3~-2℃ (capillary method)
Related Substances: Strict separation and quantitative control of 2,6-dichlorobenzyl chloride and other isomers (determined by HPLC)
Moisture: Determined by Karl Fischer method
6. Quality
|
Analysis |
Units |
Standard |
|
Assay (GC) |
% |
≥98.5 |
|
Appearance |
- |
Colorless to pale yellow transparent oily liquid |
|
Melting point |
℃ |
-3~-2 |
|
Moisture |
% |
≤0.2 |
|
Ash content |
% |
≤0.1 |
|
Acidity (as HCl) |
% |
≤0.1 |
|
Conclusion |
Qualified |
|
7. Packaging, Storage and Safety Information
7.1 Packaging
Standard: 1kg/5kg/25kg drums; 200kg full plastic drums; customizable on request
7.2 Storage
Store in a cool, dry, well-ventilated warehouse below 30°C, keep containers tightly sealed; store separately from incompatible materials such as strong oxidants, strong alkalis and food, avoid direct sunlight and open flames.
7.3 Safety Information
2,4-Dichlorobenzyl Chloride is a Class 8 corrosive substance, which is corrosive to skin, eyes and respiratory tract, and may cause burns. Appropriate personal protective equipment (face shield, gloves, goggles) should be worn during operation. For detailed handling instructions and emergency measures, please refer to the official SDS.
8. Supply and Technical Support
SNOWHITE CHEMICAL CO., LTD provides stable and reliable global supply of 2,4-Dichlorobenzyl Chloride, with core competitive strengths:
ISO 9001 certified, strict batch-to-batch quality consistency control
Mature side-chain chlorination technology, industry-leading isomer separation and impurity control capacity
Stable large-scale production capacity, annual output up to 2000 tons, fast delivery for standard bulk orders
Complete COA, SDS, TDS and full set of pharmaceutical registration documents available
Contact SNOWHITE CHEMICAL CO., LTD now to get COA, free samples and the latest quotation.
Email: shirley@snowhitechem.com
Phone: +86-25-56215758.
WhatsApp：+86-13776524331
