4-Chlorobenzyl chloride (CAS 104-83-6) is a benzyl chloride derivative used in the preparation of various organic compounds. Its structure contains a chlorine atom on the benzene ring and a chloromethyl group at the para position:
Cl–C₆H₄–CH₂Cl
These two chlorine atoms are not equivalent. The chlorine attached to the benzene ring is part of an aryl C-Cl bond, while the chlorine in the group is attached to a benzylic carbon. This difference gives 4-Chlorobenzyl chloride its characteristic reactivity.
Reactivity of 4-Chlorobenzyl Chloride
The benzyl chloride group is the main reactive site of the molecule. The benzylic carbon can undergo nucleophilic substitution with suitable reagents, allowing the chlorine in the group to be replaced by other functional groups.
The aryl chlorine normally remains unchanged under these conditions. This is useful in synthesis because the reaction can introduce a p-chlorobenzyl group while retaining the chlorine substituent on the aromatic ring.
Reaction behavior depends on the reagent and process conditions, including the type of nucleophile, solvent, temperature, and reaction time. For this reason, 4-Chlorobenzyl chloride can be used as a starting material in different synthetic routes rather than being limited to one specific type of reaction.
What Can Be Made from 4-Chlorobenzyl Chloride?
The benzylic chloride can react with oxygen-, nitrogen-, and sulfur-containing nucleophiles.
With suitable oxygen nucleophiles, it can be used to prepare p-chlorobenzyl ethers. Nitrogen-containing reagents can give p-chlorobenzyl-substituted amines and related derivatives, while sulfur nucleophiles can be used to obtain p-chlorobenzyl thioethers.
The exact product depends on the starting reagent and reaction conditions, but the basic approach is the same: the benzyl chloride group provides a site for introducing the p-chlorobenzyl fragment into another molecule.
This makes 4-Chlorobenzyl chloride useful in organic synthesis and the preparation of pharmaceutical, agrochemical, and specialty chemical intermediates.
Basic Chemical Data
The main identification and physical data for 4-Chlorobenzyl chloride CAS 104-83-6 are shown below.
|
Property |
Value |
|
CAS No. |
104836 |
|
Molecular Formula |
C₇H₆Cl₂ |
|
Molecular Weight |
161.03 g/mol |
|
Melting Point |
Approx. 27 °C |
|
Boiling Point |
Approx. 222 °C |
The melting point is close to normal room temperature. At around 20 °C, the material may be solid, while warmer conditions can bring it close to or above its melting point. This should be taken into account during storage, sampling, and transportation.
Points to Check When Sourcing 4-Chlorobenzyl Chloride
For buyers, the product specification should go beyond the stated assay.
Purity and impurity profile are important when the material is used in further synthesis. GC data can provide useful information on the composition of a batch.
Batch consistency also matters for customers using the product repeatedly in the same process. A consistent raw material can help keep downstream reaction results more predictable.
COA and SDS should be available for technical review, while packaging and transportation arrangements should be suitable for the quantity and destination.
Storage conditions also deserve attention because 4-Chlorobenzyl chloride has a melting point close to ambient temperature and is sensitive to moisture. Appropriate storage conditions should be confirmed with the supplier based on the product specification and shipping environment.
4-Chlorobenzyl Chloride Supplier — Snowhite Chemical Co., LTD.
Snowhite Chemical Co., LTD. supplies 4-Chlorobenzyl chloride (CAS 104-83-6) to customers looking for chemical raw materials and intermediates for organic synthesis and related applications.
When requesting a quotation, customers can provide the required quantity, specification, packaging, destination, and documentation requirements. This helps determine the appropriate supply option for the intended use.
Conclusion
4-Chlorobenzyl chloride combines a reactive benzyl chloride group with a chlorine substituent on the aromatic ring. The difference in reactivity between these two C-Cl bonds allows the benzyl chloride group to be used for introducing a p-chlorobenzyl fragment into other molecules.
For chemical buyers, purity, impurity control, batch consistency, documentation, packaging, and storage conditions are all worth considering when selecting a 4-Chlorobenzyl chloride supplier.
Contact Us
Contact SNOWHITE CHEMICAL CO., LTD now to get COA, free samples and the latest quotation.
Email: shirley@snowhitechem.com
Phone: +86-25-56215758
WhatsApp：+86-13776524331
