1. Overview of 4-Chlorobenzotrifluoride
4-Chlorobenzotrifluoride,commonly abbreviated as PCBTF, also known as 4-chlorobenzotrifluoride, is an important aromatic fluorine-containing fine chemical. It is widely used as an intermediate for pharmaceuticals and agrochemicals, as well as a high-performance environmentally friendly solvent recognized in various environmental regulations as a low-VOC alternative.
It is particularly valued for its chemical stability, low surface tension, and strong solvency power.
SNOWHITE CHEMICAL CO., LTD specializes in supplying bulk 4-Chlorobenzotrifluoride in three mainstream commercial grades: Industrial Grade, Solvent Grade, and Pharmaceutical Grade, with strict control of purity, isomer impurities, and moisture to meet the demands of global customers in synthesis, formulation, and pharmaceutical R&D.
Basic Chemical Information
Chemical Name: 4-Chlorobenzotrifluoride
Molecular Formula: C₇H₄ClF₃
Molecular Weight: 180.56 g/mol
CAS No.: 98-56-6
EINECS No.: 202-681-1
HS Code: 2903699000
Appearance: Colorless transparent liquid with slight aromatic odor
Solubility: Practically insoluble in water; soluble in most organic solvents such as alcohols, ethers, and aromatic hydrocarbons
UN Number: UN 2234
1.1 Physical and Chemical Properties
Physical state: Clear colorless liquid
Melting point: −35 °C
Boiling point: 136–138 °C
Density: 1.348 g/cm³ at 25 °C
Refractive index: 1.445 at 20 °C
Flash point: 37 °C (closed cup)
Stability: Stable under normal storage and transportation conditions; generally non-corrosive to most common metals under normal conditions
1.2 Main Functions
The special molecular structure of PCBTF gives it dual value in industrial applications:
The trifluoromethyl group improves lipophilicity, stability, and biological activity of downstream products
The para-chlorine atom provides an active reaction site for further synthesis and derivatization
2. Industrial Grade 4-Chlorobenzotrifluoride
Industrial Grade PCBTF is the most commonly supplied grade for large-scale chemical synthesis. It features high cost performance and stable batch consistency, suitable for conventional industrial production.
Main Applications
Key intermediate for fluorinated herbicides and acaricides, including oxyfluorfen, fomesafen, fluoroglycofen-ethyl, and lactofen
Raw material for manufacturing fluorinated aromatic intermediates such as p-trifluoromethylaniline
Intermediate for dyes and other fine chemical products
3. Solvent Grade 4-Chlorobenzotrifluoride
Solvent Grade PCBTF is a high-purity grade specially optimized for solvent applications. It is recognized as a low-VOC or VOC-exempt solvent under specific U.S. environmental regulations, making it an environmentally friendly alternative to traditional ozone-depleting solvents such as 1,1,1-trichloroethane.
It provides excellent solvency for resins while maintaining relatively low toxicity and environmental impact.
This grade is strictly controlled in terms of purity, color, moisture, and acidity to meet the formulation requirements of coatings, inks, and cleaning agents.
Main Applications
Solvent for high-performance coatings, paints, adhesives, and sealants
Carrier solvent for printing inks
Industrial cleaning agent for precision parts, electronic components, and graffiti removal
Cleaning solvent in PCB processing and semiconductor manufacturing
4. Pharmaceutical Grade 4-Chlorobenzotrifluoride
Pharmaceutical Grade PCBTF is produced through further purification processes, with ultra-high purity and extremely low impurity content. It is used as a high-value intermediate for pharmaceutical APIs and R&D.
Main Applications
Key intermediate for the synthesis of fluorinated pharmaceutical APIs
Raw material for medicinal chemistry research to improve drug bioavailability and metabolic stability
Customized raw materials for pharmaceutical R&D and production with strict quality requirements
5. Quality Control
SNOWHITE CHEMICAL CO., LTD uses Gas Chromatography (GC), Karl Fischer titration, and other standard analytical methods to ensure product quality. All specifications are based on actual testing data without estimation and refer to international industrial standards and mainstream manufacturer specifications.
Specifications Table
|
Item |
Units |
Industrial Grade |
Solvent Grade |
Pharmaceutical Grade |
|
Appearance |
— |
Colorless transparent liquid |
Colorless transparent liquid |
Colorless transparent liquid |
|
Assay (GC) |
% |
≥99.0 |
≥99.7 |
≥99.9 |
|
Dichlorobenzotrifluoride |
% |
≤0.10 |
≤0.05 |
≤0.01 |
|
Moisture |
ppm |
≤150 |
≤100 |
≤50 |
|
Acidity (as HCl) |
% |
≤0.003 |
≤0.002 |
≤0.001 |
|
Color (APHA) |
— |
≤30 |
≤20 |
≤10 |
|
Residue on Ignition |
% |
≤0.01 |
≤0.005 |
≤0.005 |
6. Packaging and Storage
6.1 Packaging
Standard packaging: 200L galvanized iron drums, 200kg or 250kg per drum
Small packaging: 25kg, 50kg sealed plastic drums
Bulk packaging: 1200kg IBC tanks
6.2 Storage
Store in a cool, dry, and well-ventilated warehouse below 30 °C. Keep tightly sealed and away from direct sunlight, moisture, strong oxidants, strong bases, and sources of ignition. Store separately from food and daily-use products.
7. Safety Information
PCBTF is a Class 3 flammable liquid and may cause irritation to skin, eyes, and the respiratory tract. Appropriate personal protective equipment should be used during handling.
It is listed under California Proposition 65 for reproductive toxicity. It is not classified as a carcinogen based on currently available data.
For detailed handling and safety measures, please refer to the official SDS.
8. Why Choose SNOWHITE CHEMICAL CO., LTD?
Stable supply capacity for three mainstream grades of PCBTF
Strict control of isomer impurities and consistent batch quality
Complete COA, SDS, and export documentation
Professional Q&A and support for intermediate synthesis and solvent formulation
Customizable specifications according to customer requirements
Contact SNOWHITE CHEMICAL CO.,LTD now to get COA, free samples and the latest quotation.
Email: shirley@snowhitechem.com
Phone: +86-25-56215758.
WhatsApp：+86-13776524331
