If you’re making pyrethroid insecticides or working on an API like granisetron or pyrimethamine, you’ve probably come across 2-chlorobenzyl cyanide. It’s a versatile intermediate. But here’s the thing—picking the wrong grade can mess with your costs, product quality, or even regulatory compliance.
At SNOWHITE CHEMICAL, we supply both industrial and pharmaceutical intermediate grades. This post breaks down the differences so you can pick the right one without overpaying or under-delivering.
1. What Is 2-Chlorobenzyl Cyanide?
Chemical name: 2-Chlorobenzyl cyanide
CAS: 2856-63-5
Formula: C₈H₆ClN
Appearance: White to pale yellow solid or liquid at room temperature (melting point 21–24°C)
Solubility: Soluble in ethanol, diethyl ether, and most organic solvents
The cyano group and chlorine substitution make it a useful building block for more complex molecules. That’s why it shows up in agrochemicals, pharmaceuticals, dyes, and fine chemicals.
2. Industrial Grade
For Large-Scale, Cost-Driven Synthesis
Who it’s for:
Manufacturers of pesticides, dyes, fragrances (non-pharma)
Buyers who can tolerate moderate impurity levels but need stable supply and fair pricing
Typical specs
|
Parameter |
Industrial Grade |
|
Purity (GC) |
≥ 98.0% |
|
Moisture |
≤ 0.5% |
|
Heavy metals (Pb) |
≤ 50 ppm |
Typical applications
Pyrethroid insecticides
Anthraquinone dyes
Fragrance intermediates
What you get: Cost-effective, stable quality, suitable for ton-scale orders.
3. Pharmaceutical Intermediate Grade
Built for API Development and Regulatory Compliance
Who it’s for:
API manufacturers, CDMOs
Anyone who needs to meet ICH, GMP, FDA, or CEP requirements
Typical specs
|
Parameter |
Pharmaceutical Grade |
|
Purity (HPLC) |
≥ 99.5% |
|
Total impurities |
≤ 0.1% |
|
Moisture |
≤ 0.1% |
|
Residual solvents (e.g., methanol) |
≤ 50 ppm |
|
Heavy metals (Pb) |
≤ 10 ppm |
Typical applications
Granisetron HCl (anti-emetic)
Pyrimethamine (antimalarial)
Cardiac glycosides
What you get: cGMP manufacturing, full batch traceability, stability data included.
4. Industrial vs. Pharmaceutical
|
|
Industrial Grade |
Pharmaceutical Grade |
|
Purity test |
GC ≥ 98.0% |
HPLC ≥ 99.5% |
|
Impurity control |
Heavy metals ≤ 50 ppm |
Heavy metals ≤ 10 ppm + single impurities controlled |
|
Regulatory standard |
Basic chemical norms |
cGMP / ICH Q7 / Q3D |
|
Cost position |
Lower |
Premium |
|
Typical buyers |
Pesticide & dye makers |
Pharma companies & CDMOs |
5. FAQ – What People Usually Ask
Can I order a small package of pharmaceutical grade for trials?
Yes – we offer 100g, 500g, and 1kg sizes for R&D and pilot batches.
Can I use industrial grade to make an API?
Technically you could, but we don’t recommend it. Industrial grade has looser impurity limits, which can affect API purity and stability. Plus, it won’t pass regulatory audits.
Can you customize residual solvent or heavy metal limits?
Yes – we can adjust specs to meet your needs, like lowering a specific solvent residue or removing certain heavy metals.
Do you provide RoHS, REACH, or other regional declarations?
Yes – just tell us the destination, and we’ll provide what’s needed.
6. Why People Choose SNOWHITE CHEMICAL CO., LTD
Process – Distillation plus recrystallization gives consistent purity batch after batch.
Documentation – You get COAs, stability reports, method validation – the whole package.
Logistics – Compliant packaging and temperature-controlled shipping.
Flexibility – From industrial to high-purity pharma grade, from kilos to tons.
Contact Us
Contact SNOWHITE CHEMICAL CO., LTD now to get COA, free samples and the latest quotation.
Email: shirley@snowhitechem.com
Phone: +86-25-56215758
WhatsApp：+86-13776524331
