1. Overview of 2,4-Dichlorotoluene
2,4-Dichlorotoluene (CAS 95-73-8) is a vital chlorinated aromatic intermediate, widely used in the synthesis of dyes, pigments, pharmaceuticals, and agrochemicals.
We supply bulk Technical Grade and Pharma-grade Intermediate products, utilizing advanced rectification and separation technology to strictly control isomer impurities (especially 2,6-isomer) and Residual chlorinated impurities.
SNOWHITE CHEMICAL CO., LTD products are widely used in the production of azo dyes, dye intermediates, herbicide synthesis, and fine chemical processing worldwide.
Basic Chemical Information:
Chemical Name: 2,4-Dichlorotoluene
Molecular Formula: C₇H₆Cl₂
Molecular Weight: 161.03 g/mol
CAS No.: 95-73-8
Appearance: Colorless to pale yellow liquid
Odor: Characteristic aromatic odor
1.1 Physical & Chemical Properties
Physical State: Colorless to pale yellow oily liquid
Density (20°C): 1.252 g/cm³
Melting Point: -14°C; Boiling Point: 200°C
Refractive Index (20°C): 1.548
Flash Point: 85°C (closed-cup), combustible
Solubility: Insoluble in water, soluble in most organic solvents such as ethanol, ether, and aromatic hydrocarbons, and most organic solvents
Stability: Stable under normal conditions; avoid contact with strong oxidizing agents and strong bases.
1.2 Functional Behavior & Mechanism of Action
The industrial application value of 2,4-Dichlorotoluene relies on the reactivity of the chlorine atoms at the 2- and 4-positions and the methyl group:
The Chlorine at the 4-position is highly reactive towards nucleophilic substitution, serving as a key site for amination or hydrolysis reactions.
The Chlorine at the 2-position is sterically hindered, providing specific selectivity in stepwise synthesis.
Distinction from 2,6-Isomer: Unlike 2,6-Dichlorotoluene, where both chlorine atoms are sterically hindered by the methyl group, the 4-chlorine in 2,4-Dichlorotoluene is more accessible for chemical modification, making it a preferred intermediate for asymmetric synthesis.
1.2.1 Practical Significance in Applications
For Dyes & Pigments:
Core intermediate for azo dyes and organic pigments (e.g., Diarylide yellow pigments).
For Pharmaceuticals:
Used as an intermediate in the synthesis of certain pharmaceutical compounds, including non-steroidal anti-inflammatory drug intermediates.
For Agrochemicals:
Precursor for synthesizing specific herbicides and fungicides.
For Industrial Fine Chemicals:
Raw material for dye intermediates and corrosion inhibitors.
2. Technical Grade 2,4-Dichlorotoluene
2.1 Product Overview
Typically contains ≥98.5–99.0% 2,4-isomer with controlled 2,6-dichlorotoluene impurity (<0.5–1.5% depending on specification).
2.2 Typical Applications
Widely used in the manufacturing of azo dyes and pigments; serves as a high-boiling solvent or heat transfer medium in specific industrial processes.
3. Pharma-grade Intermediate
3.1 Product Overview
With strict control of 2,6-Dichlorotoluene isomer content (<0.5% or customized), free chlorine, and moisture. Dedicated to high-end pharmaceutical synthesis.
3.2 Typical Applications
Used in the synthesis of active pharmaceutical ingredients (APIs) where regioselectivity is critical; the low isomer impurity ensures high yield and purity in downstream coupling reactions.
4. Production Process
Industrial production mainly adopts the Direct Chlorination of Toluene:
Toluene is reacted with chlorine gas in the presence of a catalyst (typically Iron or Ferric Chloride).
The reaction produces a mixture of monochlorotoluene, 2,4-Dichlorotoluene, and 2,6-Dichlorotoluene.
Separation: High-efficiency vacuum distillation columns are used to separate 2,4-Dichlorotoluene from the 2,6-isomer and other by-products based on boiling point differences.
5. Quality Inspection & Control
We have established a quality control system focusing on purity, isomer ratio, color, and acidity.
Technical Grade Specification
|
Analysis |
Units |
Standard |
|
Assay (GC) |
% |
≥99.0 |
|
Appearance |
- |
Colorless to pale yellow liquid |
|
Density (at 20℃) |
g/cm³ |
1.250 - 1.255 |
|
Moisture |
% |
≤0.05 |
|
Acidity (as HCl) |
% |
≤0.01 |
|
Conclusion |
Qualified |
|
6. Packaging, Storage & Safety Information
6.1 Packaging
Standard: 250kg Galvanized Iron Drum or ISO Tank.
Customized packaging available upon customer request.
6.2 Storage
Store in a cool, ventilated, and dry warehouse.
Keep containers tightly sealed.
Store separately from strong oxidizing agents, strong alkalis, and aluminum powder.
7. Supply & Technical Support
SNOWHITE CHEMICAL CO., LTD provide global supply of 2,4-Dichlorotoluene, with support systems including:
ISO 9001 certified quality management system.
Advanced isomer separation technology to meet specific ratio requirements.
Stable large-scale production capacity.
Complete COA, SDS, and TDS available.
Contact Us
Contact SNOWHITE CHEMICAL CO., LTD now to get COA, free samples and the latest quotation.
Email: shirley@snowhitechem.com
Phone: +86-25-56215758
WhatsApp：+86-13776524331
